Drug Delivery : Engineering Principles for Drug Therapy.
Part I. Introductory material 1. Introduction2. Drug administration and drug effectivenessPart II. Fundamentals 3. Diffusion and drug dispersion4. Diffusion in biological systems5. Drug permeation through biological barriers6. Drug transport by fluid motion7. Pharmacokinetics of drug distributionPar...
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| Format: | Electronic eBook |
| Language: | English |
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Oxford University Press,
2001
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| Local Note: | ProQuest Ebook Central |
Table of Contents:
- Cover Page; Title Page; Copyright Page; Dedication; Preface; Contents; Part I Introductory material; 1 Introduction; 1.1 Historical perspective; 1.2 The aim and structure of this book; 2 Drug administration and drug effectiveness; 2.1 The state of the art; 2.2 Two views of the future; Summary; Part II Fundamentals; 3 Diffusion and drug dispersion; 3.1 Random walks; 3.2 Equations for the diffusive flux (Fick's law); 3.3 Equations of mass conservation (Fick's second law); 3.4 Solutions to the diffusion equation with no solute elimination or generation.
- 3.5 Solutions to the diffusion equation with solute binding and elimination3.6 A few applications; Summary; 4 Diffusion in biological systems; 4.1 Measurement of diffusion coefficients; 4.2 Diffusion in water; 4.3 Diffusion in polymer solutions and gels; 4.4 Diffusion in the extracellular space; 4.5 Diffusion with binding in tissues; 4.6 Diffusion within cells; 4.7 Diffusion and reaction; Summary; 5 Drug permeation through biological barriers; 5.1 Mobility of lipids and proteins in the membrane; 5.2 Permeation through lipid membranes; 5.3 Permeation through porous membranes.
- 5.4 Permeation is enhanced by membrane proteins5.5 Permeation through cell layers; Summary; 6 Drug transport by fluid motion; 6.1 Blood movement in the circulatory system; 6.2 Interstitial fluid movement; 6.3 Fluid movement in the lymphatic circulation; 6.4 Fluid movement in the brain; Summary; 7 Pharmacokinetics of drug distribution; 7.1 Compartimental models; 7.2 Physiological models; 7.3 Patterns of mixing in tissues and organs; 7.4 The problem of scale; Summary; Part III Drug delivery systems; 8 Drug modification; 8.1 Enhancing agent solubility; 8.2 Enhancing agent stability.
- 8.3 Regulating agent permeability8.4 Drug targeting and drug valency; Summary; 9 Controlled drug delivery systems; 9.1 Reservoir and transdermal delivery systems; 9.2 Matrix delivery systems; 9.3 Hydrogel delivery systems; 9.4 Degradable delivery systems; 9.5 Particulate delivery systems; 9.6 Responsive delivery systems; Summary; 10 Case studies in drug delivery; 10.1 Controlled delivery of systemic therapy; 10.2 Implants for local drug delivery; 10.3 Topically applied devices for controlled release; 11 Postscript; Appendix A Overview of polymeric biomaterials; A.1 Non-degradable polymers.
- A.1.1 Silicone elastomersA. 1.2 Poly[ethylene-co-(vinyl acetate)]; A.1.3 Polyurethanes; A.1.4 Other important polymers; A.2 Biodegradable polymers; A.2.1 Polyesters; A.2.2 Copolymers of methyl vinyl ether and maleic anhydride; A.2.3 Poly(ortho esters); A.2.4 Polyanhydrides; A.2.5 Poly(amino acids); A.2.6 Phosphorus-containing polymers; A.2.7 Polycarbonates and poly(iminocarbonates); A.2.8 Polydioxanone; A.3 Water-soluble polymers; A.3.1 Naturally occurring polymers; A.3.2 Acrylates and acrylamides; A.3.3 Polyethylene glycol); Appendix B Useful data and nomenclature.
