Estrogen effects on traumatic brain injury : mechanisms of neuroprotection and repair /
This book demystifies, deconstructs, and simultaneously humanizes the field of estrogen-mediated neuroprotection following TBI, making the subject approachable to both researchers and advanced students. Bringing together leading researchers and practitioners to explain the basis for their work, meth...
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Full text (MCPHS users only) |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Amsterdam :
Academic Press, an imprint of Elsevier,
2015
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| Subjects: | |
| Local Note: | ProQuest Ebook Central |
Table of Contents:
- Front Cover; Estrogen Effects on Traumatic Brain Injury; Copyright Page; Contents; About the Editor; List of Contributors; About the Contributors; Taura Barr; George E. Barreto; Suzanne R. Burstein; Francisco Capani; Laura L. Carruth; Nicolas Diotel; Miranda Reed; Colin J. Saldanha; James Simpkins; Farida Sohrabji; Introduction; Why Should I Care?; Rationale and Scope of the Book; 1 Historical Antecedents; Introduction; The "INS AND OUTS" of TBI: An Overview; A History of TBI from Antiquity Through the 19th Century; From the Bench to the Clinic: TBI in the 20th and 21st Century.
- Conclusions and Future ThoughtsAcknowledgements; References; 2 Estrogen Actions in the Brain; Introduction; Steroid Hormones; Estrogens; Estrogen Receptors; Blood-Brain Barrier and Glial Cells; Estradiol and Brain Sexual Differentiation; Rapid Estrogen Signaling in the Brain; Estrogen-Sensitive Brain Regions; Sexually Dimorphic Brain Regions; Hippocampus; Cerebellum; Neurotransmitter Systems; Basal Forebrain Cholinergic System; Midbrain and Brainstem Serotonergic System; Catecholaminergic Neurons; Estrogens, Aging, and Neuroprotection; Additional Physiological Effects of Estrogens on the Body.
- Conclusions and New DirectionsReferences; 3 Induction of Estrogen Response Following Injury; Introduction; Reactive Gliosis Following Injury; New Roles for Glial Cells as Steroid Synthesizing Cells; Induction of Glial Aromatase Following Injury; Neuroinflammation Induces Glial Aromatase Independent of Injury; Sex Differences in Cytokine Response Following Injury; Sex Differences in Glial Aromatase Expression Following Injury; Conclusion and Future Directions; Acknowledgements; References; 4 Astrocytic Aromatization and Injury; Aromatase is Expressed in Astroglia.
- What Induces Astrocytic Aromatase Expression?Glial Estrogen Synthesis and Neuroprotection; Apoptosis and Secondary Degeneration; Injury-Induced Cyto- and Neurogenesis; Summary and Future Directions; Further Reading; 5 Aromatase and Estrogens: Involvement in Constitutive and Regenerative Neurogenesis in Adult Zebrafish; Introduction; Unique Features Exhibited by the Brain of Teleost Fish; Neurosteroid Synthesis and Signaling in the Brain of Adult Zebrafish; Aromatase B Expression is Restricted to Radial Glia Acting Like Neural Stem Cells.
- Involvement of Aromatase and Estrogens in Adult Neurogenesis and Brain Repair in ZebrafishComparison with Mammalian and Nonmammalian Models; Hypothesis and Perspectives for Estrogen Involvement in Neurogenesis Regarding New Advances in Zebrafish and New Literature ... ; Conclusion; References; 6 Neuroprotection by Exogenous Estrogenic Compounds Following Traumatic Brain Injury; Introduction; Neuroprotective Steroids; Estrogens, Progestagens and Androgens as Protective Compounds; Selective Estrogen Receptor Modulators; Selective Tissue Estrogenic Activity Regulator; TBI Protection Strategies.
