The Neurobiology of Schizophrenia.
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Full text (MCPHS users only) |
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| Other Authors: | |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Saint Louis :
Elsevier Science,
2016
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| Subjects: | |
| Local Note: | ProQuest Ebook Central |
Table of Contents:
- Front Cover; The Neurobiology of Schizophrenia; Copyright Page; Contents; List of Contributors; Acknowledgments; I. Introduction; 1 Historical and Clinical Overview: Implications for Schizophrenia Research; Introduction; A Brief History of the Definition of Schizophrenia; Lessons From Therapeutic Approaches; The Neurobiology of Schizophrenia; References; II. The Genetic and Epigenetic Basis of Schizophrenia; 2 Progress and Prospects for Endophenotypes for Schizophrenia in the Time of Genomics, Epigenetics, Oscillatory Brain Dynam ... ; Endophenotypes in Schizophrenia: Current Status.
- An Emerging Frontier for Endophenotypes: EpigeneticsA New Frontier for Endophenotypes: Brain Connectivity Dynamics; Limitations and Future Directions; References; 3 Insights From Genome-Wide Association Studies (GWAS); The Pre-GWAS Era: Linkage and Candidate Gene Association Studies; The Developments That Made GWAS Possible; The Principle of GWAS; GWAS Findings in Schizophrenia; Genetic Relationship Between Schizophrenia and Other Psychiatric Disorders; Were GWAS of Schizophrenia Successful So Far and Should They Continue?; Future Directions; References.
- 4 Sequencing Approaches to Map Genes Linked to SchizophreniaIntroduction and Background; Next-Generation Sequencing; Exome Versus Whole Genome; Sequencing Studies to Date; Conclusions; Future Directions; References; 5 Epigenetic Approaches to Define the Molecular and Genetic Risk Architectures of Schizophrenia; Introduction; An Epigenetic Link Between Environmental Risk Factors and Schizophrenia; Evidence From Human Studies; Evidence From Animal Studies; DNA Methylation in Schizophrenia; DNA Methylation and Gene Regulation in the Brain; DNA Methylation Changes in Schizophrenia.
- Studies in the Peripheral Tissue and Possible Epigenetic Biomarkers in SchizophreniaEpigenetic Approaches to the Molecular and Genetic Risk Architectures of Schizophrenia; Do Epigenetic Mechanisms Contribute to Long-Lasting Alterations in Gene Expression in Schizophrenia Brain?; Functional Neuroepigenomics Could Inform About Disease-Associated Genetic Risk Polymorphisms; Higher-Order Chromatin and the Genetic Risk Architecture of Schizophrenia; Epigenetic Mechanisms and the Treatment of Schizophrenia; Future Directions; Chromatin-Modifying Drugs: A Future Treatment for Schizophrenia?
- Comprehensive, Region-Specific, and Cell Type-Specific Epigenome Mappings in the BrainLarger and More Ambitious Clinical Studies; Acknowledgment; References; 6 Exploring Neurogenomics of Schizophrenia With Allen Institute for Brain Science Resources; Introduction; Introduction to the Portal; Mouse Atlas Resources; Common Reference Space in the Mouse Brain; Integrated Search and Visualization in the Allen Brain Atlas; The Mouse Developmental Atlas; Connectivity in the Mouse Brain; Human Atlas Resources; The Allen Human Brain Atlas; BrainSpan Atlas of the Developing Human Brain.
