In vitro and in vivo development of a topical drug for the treatment of equine skin cancer - based on naturally occurring and synthetically modified substances in plane bark

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Bibliographic Details
Online Access: Full text (MCPHS users only)
Main Author: Weber, Lisa Annabel
Format: Electronic eBook
Language:English
Published: Göttingen : Cuvillier Verlag, 2021
Series:Wissenschaftliche Reihe der Klinik für Pferde.
Subjects:
Local Note:ProQuest Ebook Central

MARC

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245 1 0 |a In vitro and in vivo development of a topical drug for the treatment of equine skin cancer - based on naturally occurring and synthetically modified substances in plane bark  |h [electronic resource]. 
260 |a Göttingen :  |b Cuvillier Verlag,  |c 2021. 
300 |a 1 online resource (141 p.). 
490 1 |a Wissenschaftliche Reihe der Klinik für Pferde ;  |v v.51 
500 |a Description based upon print version of record. 
505 0 |a Intro -- LIST OF ABBREVIATIONS -- SUMMARY -- ZUSAMMENFASSUNG -- 1. Introduction -- 1.1. The equine malignant melanoma -- 1.2. The equine sarcoid: an overview -- 1.3. Topical drug application -- 1.4. Naturally occurring substances in plane bark and their syntheticallymodified derivatives -- 1.5. Hypotheses and aims of the thesis -- 2. Manuscript I:Betulinic acid shows anticancer activity against equine melanoma cells andpermeates isolated equine skin in vitro -- 2.1. Supplemental data 
505 8 |a 3. Manuscript II:In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate asa topical treatment for equine skin cancer -- 4. Manuscript III:Concentration profiles and safety of topically applied betulinic acid andNVX-207 in eight healthy horses -- A randomized, blinded, placebocontrolled,crossover pilot study -- 5. Manuscript IV:Effects of topically applied betulinic acid and NVX-207 on early stageequine melanoma -- A prospective, randomized, double-blind, placebocontrolledpilot study -- 6. General discussion -- 6.1. Summarized findings -- 6.2. Interpretation of the findings 
505 8 |a 7. Major findings and conclusions -- 8. Future perspectives -- 9. References -- Affidavit -- Acknowledgements 
590 |a ProQuest Ebook Central  |b Ebook Central Academic Complete 
650 0 |a Horses  |x Diseases. 
650 0 |8 7 p  |a Skin  |x Cancer. 
650 0 |8 8 p  |a Bark. 
650 7 |a bark (plant material)  |2 aat 
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776 0 8 |i Print version:  |a Weber, Lisa Annabel  |t In vitro and in vivo development of a topical drug for the treatment of equine skin cancer - based on naturally occurring and synthetically modified substances in plane bark  |d Göttingen : Cuvillier Verlag,c2021  |z 9783736974326 
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