Pharmaceutical blending and mixing /
Written in four parts, this book provides a dedicated and in-depth reference for blending within the pharmaceutical manufacturing industry. It links the science of blending with regulatory requirements associated with pharmaceutical manufacture. The contributors are a combination of leading academic...
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Full text (MCPHS users only) |
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| Other Authors: | , , , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Chichester, Sussex, UK ; Hoboken, NJ :
Wiley,
2015
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| Subjects: | |
| Local Note: | ProQuest Ebook Central |
Table of Contents:
- Title Page; Copyright Page; Contents; Contributor List; Preface; Part I Fundamentals of Mixing; Chapter 1 Mixing Theory; 1.1 Introduction; 1.2 Describing Mixtures; 1.3 Scale of Scrutiny; 1.4 Quantifying Mixedness for Coarse and Fine-Grained Mixtures; 1.4.1 Coarse and Fine-Grained Mixtures; 1.4.2 Scale and Intensity of Segregation; 1.5 Determining the End-Point of Mixing: Comparison of Mixing Indices; 1.6 Continuous Flow Mixers; 1.6.1 Idealized Mixing Patterns; 1.6.2 Residence Time Distributions; 1.6.3 Back-Mixing and Filtering of Disturbances Using a CSTR; References.
- Chapter 2 Turbulent Mixing Fundamentals2.1 Introduction; 2.2 The Velocity Field and Turbulence; 2.3 Circulation and Macro-Mixing; 2.4 Fully Turbulent Limits and the Scaling of Turbulence; 2.5 The Spectrum of Turbulent Length Scales, Injection of a Scalar (Either Reagent or Additive) and the Macro-, Meso- and Micro-Scales of Mixing; 2.6 Turbulence and Mixing of Solids, Liquids, and Gases; 2.7 Specifying Mixing Requirements for a Process; 2.8 Conclusions; Notation; Roman Characters; Greek Characters; References; Chapter 3 Laminar Mixing Fundamentals; 3.1 Laminar Flows.
- 3.2 Mixing in Laminar Flows3.2.1 Chaos and Laminar Chaotic Mixing; 3.2.2 Granular Chaotic Mixing; 3.3 Recent Advances; References; Chapter 4 Sampling and Determination of Adequacy of Mixing; 4.1 Introduction, Process Understanding, and Regulations; 4.2 Theory of Sampling; 4.3 Sampling of Pharmaceutical Powder Blends; 4.4 Stratified Sampling Approach; 4.5 Testing; 4.6 Process Knowledge/Process Analytical Technology; 4.7 Real Time Spectroscopic Monitoring of Powder Blending; 4.8 Looking Forward, Recommendations; 4.9 Conclusion; 4.10 Acknowledgments; References; Part II Applications.
- Chapter 5 Particles and Blending5.1 Introduction; 5.2 Particle Geometry; 5.2.1 Particle Size and Size Distribution; 5.2.2 Particle Shape and Shape Distribution; 5.3 Particle Interactions; 5.3.1 van der Waals Forces; 5.3.2 Electrostatic Forces; 5.3.3 Adsorbed Liquid Layers and Liquid Bridges; 5.3.4 Solid Bridges; 5.3.5 Use of AFM to Measure Interparticle Forces; 5.3.6 Interparticle Friction; 5.4 Empirical Investigations of Particles and Blending; 5.4.1 Blending of Powders; 5.4.2 Impact of Particle Geometry on Blending; 5.4.3 Impact of Interparticle Forces on Blending.
- 5.4.4 Impact of Blender Conditions on Blending5.5 Simulation Techniques; 5.5.1 Full Physics Models Using Discrete Element Modeling; 5.5.2 Continuum Models; 5.5.3 Cellular Automata; References; Chapter 6 Continuous Powder Mixing; 6.1 Introduction; 6.2 Overview; 6.3 Theoretical Characterization; 6.3.1 Residence Time Distribution (RTD) Modeling; 6.3.2 Variance Reduction Ratio; 6.4 Experimental Characterization; 6.4.1 Hold-Up; 6.4.2 Residence Time Distribution (RTD) Measurements; 6.4.3 Mean Strain; 6.5 Continuous Mixing Efficiency; 6.5.1 Variance Reduction Ratio; 6.5.2 Blend Homogeneity.
