Vanilloid Receptor TRPV1 in Drug Discovery : Targeting Pain and Other Pathological Disorders /
This book discusses recent advances in biology, chemistry, and pharmacology at both the preclinical and clinical stage of transient receptor potential vanilloid subtype 1 (TRPV1) drug discovery research. Chapters explore the impact and drug targeting of TRPV1 in inflammation, migraine, arthritis, an...
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Full text (MCPHS users only) |
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| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Hoboken, N.J. :
Wiley,
2010
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| Subjects: | |
| Local Note: | ProQuest Ebook Central |
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| 245 | 0 | 0 | |a Vanilloid Receptor TRPV1 in Drug Discovery : |b Targeting Pain and Other Pathological Disorders / |c edited by Arthur Gomtsyan, Connie R. Faltynek. |
| 260 | |a Hoboken, N.J. : |b Wiley, |c ©2010. | ||
| 300 | |a 1 online resource (xviii, 457 pages) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
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| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a TRP channels and human diseases / Bernd Nilius and Rudi Vennekens -- Role of TRP channels in pain : an overview / Arpad Szallasi -- Biochemical pharmacology of TRPV1 : molecular integrator of pain signals / Carol S. Surowy, Philip R. Kym, Regina M. Reilly -- TRPV1 genetics / Ruslan Dorfman [and others] -- TRPV1 and inflammatory pain / Anindya Bhattacharya, Sonya G. Lehto, and Narender R. Gavva -- Role of TRPV1 receptors in osteoarthritis pain / Shailen K. Joshi and Prisca Honore -- TRPV1 and bone cancer pain / Juan Miguel Jimenez-Andrade and Patrick Mantyh -- TRPV1 in visceral pain and other visceral disorders / Antonio Avelino and Francisco Cruz -- TRPV1 receptors and migraine / Philip R. Holland and Peter J. Goadsby -- TRPV1 in neuropathic pain, and neurological and neuropsychiatric disorders / Enza Palazzo [and others] -- Aryl-urea class and related TRPV1 antagonists / Arthur Gomtsyan -- 2-pyridinylpiperazine carboxamide class and related TRPV1 antagonists / Natalie A. Hawryluk and Nicholas I. Carruthers -- TRPV1 agonist approaches for pain management / Keith R. Bley -- The TRPV1 channel in normal thermoregulation : what have we learned from experiments using different tools? / Andras Garami [and others] -- Role of TRPV1 in respiratory diseases / Serena Materazzi [and others] -- Role of TRPV1 in diabetes / Hubert Tsui [and others]. | |
| 520 | |a This book discusses recent advances in biology, chemistry, and pharmacology at both the preclinical and clinical stage of transient receptor potential vanilloid subtype 1 (TRPV1) drug discovery research. Chapters explore the impact and drug targeting of TRPV1 in inflammation, migraine, arthritis, and cancer; as well as the development of analgesic drugs. The TRPV1 receptor is not limited to pain only, and the book covers its role in chronic cough, bladder disorders, and asthma. The book features data relevant to the therapeutic potential of TRPV1 and the medicinal chemistry involved in designi. | ||
| 546 | |a English. | ||
| 588 | 0 | |a Print version record. | |
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Analgesics. | |
| 650 | 0 | |a Drugs |x Design. | |
| 650 | 0 | |a Nociceptors. | |
| 650 | 0 | |a Inflammation. | |
| 650 | 2 | |a TRPV Cation Channels |x physiology | |
| 650 | 2 | |a Analgesics |x pharmacology | |
| 650 | 2 | |a Analgesics |x therapeutic use | |
| 650 | 2 | |a Drug Discovery | |
| 650 | 2 | |a Pain |x drug therapy | |
| 650 | 2 | |a Analgesics | |
| 650 | 2 | |a Drug Design | |
| 650 | 2 | |a Nociceptors | |
| 650 | 2 | |a Inflammation | |
| 700 | 1 | |a Gomtsyan, Arthur. | |
| 700 | 1 | |a Faltynek, Connie R. | |
| 758 | |i has work: |a Vanilloid receptor TRPV1 in drug discovery (Text) |1 https://id.oclc.org/worldcat/entity/E39PD3q8mvxrGMjDDGTWT8YGd3 |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
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