Pathogenic Neisseria : genomics, molecular biology and disease intervention /
The human pathogens Neisseria meningitidis and Neisseria gonorrhoeae are exquisitely adapted to life within the human mucosa, their only natural niche. N. meningitidis is the causative agent of rapidly transmissible meningitis and septic shock. Vaccines developed to control this pathogen can be rend...
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| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Norfolk, UK :
Caister Academic Press,
2014
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| Subjects: | |
| Local Note: | ProQuest Ebook Central |
Table of Contents:
- Contributors; Preface; 1: Genomics and Reference Libraries; Introduction; Bacterial typing using nucleotide sequencing; Clonal complexes; Sequence typing databases; Antigen typing; Antibiotic resistance genes; Data management; The Bacterial Isolate Genome Sequence Database (BIGSdb) platform; Genome Comparator and whole genome MLST; Neisseria genomes on PubMLST.org; Community-based annotation; Automated extraction of clinically relevant information; Neisseria speciation using standard and ribosomal MLST; Discussion; Future trends.
- 2: Transcriptional Regulatory Proteins in the Pathogenic NeisseriaIntroduction; Clinical and biological relevance of Neisseria transcriptional regulators in general and Fur in particular; Mechanism of regulation of the ferric uptake regulator (Fur); Fur acts as a global regulator in the pathogenic Neisseria; Direct Fur regulation; Indirect Fur regulation; Fur cross-talk with other regulatory circuits; Conclusions; Future trends; 3: The Regulatory Small RNAs of Neisseria; Introduction; Identification of sRNAs of N. meningitidis and N. gonorrhoeae; Functional analysis of sRNAs in Neisseria.
- ConclusionsFuture trends; Inter- and Intraspecies Transformation in the Neisseria: Mechanism, Evolution and DNA Uptake Sequenc; Introduction; Inter- and intraspecies transformation in the neisseriae; Restriction modification and transformation; Transformation mechanism; DNA uptake sequence specificity of the Neisseria; Discussion and conclusions; Future trends; 5: Pathogenic Neisseria: Neither Aerobes nor True Anaerobes, but Dedicated Microaerophiles; Introduction; Aerobic growth of neisserial species; Why might Neisseria not be able to grow anaerobically?
- Effect of oxygen limitation on serum resistance and pathogenicityFNR in the gonococcus; Gonococcal survival during oxygen starvation; Reduction of nitric oxide, the toxic product of nitrite reduction; Neisserial denitrification and pathogenicity; Other physiological roles of the neisserial FNR transcription activators; Evidence that the meningococcal FNR is less oxygen sensitive than the gonococcal FNR; Outer membrane lipoproteins as the first line of defence against chemical attack by the host; Electron transfer to outer membrane lipoproteins; Overview of nitrosative damage.
- Repair of nitrosative damageConclusions: niche adaptation and pathogenicity; Future trends; 6: Peptidoglycan Metabolism and Fragment Production; Introduction; Overview of Neisseria cell wall structure; Cell wall growth, septation and separation; Autolysis; Release of PG fragments by N. gonorrhoeae; Enzymes involved in peptidoglycan liberation from the cell wall; Peptidoglycan acetylation; Recycling of peptidoglycan fragments; Starvation response in the absence of peptidoglycan recycling; Meningococcal PG fragment release; Responses to released PG fragments.
