Essential and Non-essential Metals : Carcinogenesis, Prevention and Cancer Therapeutics.
This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, I...
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Cham :
Springer International Publishing,
2017
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| Series: | Molecular and integrative toxicology.
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| Subjects: | |
| Local Note: | ProQuest Ebook Central |
Table of Contents:
- Preface; Acknowledgements; Contents; Contributors; Chapter 1: Calcium Channels and Pumps: Importance During Lactation as Potential Targets for Breast Cancer; 1.1 Introduction; 1.2 Ca2+ Transport Mechanisms in Epithelial Cells; 1.3 Lactation; 1.4 Ca2+ Transport During Lactation; 1.4.1 Basolateral Ca2+ Influx in Mammary Epithelial Cells During Lactation; 1.4.2 Ca2+ Secretion from Mammary Epithelial Cells During Lactation; 1.4.3 Ca2+ Efflux from Mammary Epithelial Cells During Lactation; 1.5 Breast Cancer; 1.6 Ca2+ Signaling and Transport and Breast Cancer; 1.6.1 ORAI1 and Breast Cancer.
- 1.6.2 SPCA2 and Breast Cancer1.6.3 PMCA2 and Breast Cancer; 1.7 Summary; References; Chapter 2: Tumor Development Through the Mg2+nifying Glass; 2.1 Introduction; 2.2 Magnesium and Carcinogenesis; 2.3 Magnesium and Primary Tumor Growth; 2.4 Magnesium and Tumor Metastasis; 2.5 Magnesium and Cancer Therapy; 2.6 Involvement of the TRPM7 Cation Channel; 2.7 Conclusion; References; Chapter 3: Selenium: Roles in Cancer Prevention and Therapies; 3.1 Selenium Is an Essential Element for Animals, and Selenium Deficiency Is Associated with Multiple Diseases.
- 3.2 Naturally Occurring Selenium Compounds in Diet and Selenium in Supplements3.3 Cellular Metabolism of Selenium: Transport, Incorporation, Methylation, and Glutathiolation; 3.3.1 Selenium Uptake; 3.3.2 Incorporation to Selenoproteins; 3.3.3 Reduction and Conjugation of Selenium with GSH; 3.3.4 Methylation of Selenium; 3.4 Selenoproteins and Their Expression and Function in Cancers; 3.4.1 Selenoprotein Cellular Function; 3.4.2 Roles of Selenoproteins in Cancer; 3.5 Association of Selenium Level/Selenoprotein SNPs with Cancer Pathologies.
- 3.6 Clinical Application of Small Selenium Compounds in Cancer Prevention and Treatment3.6.1 Selenium Compounds Applied in Cancer Prevention and Treatment as Antioxidant; 3.6.2 Small-Molecule Selenium Compounds Used in Cancer Prevention and Therapies; 3.7 Regulation of Oncology Signals by Selenium Compounds; 3.7.1 Inorganic Selenite Signaling; 3.7.2 Selenomethione (SeMet) Action in Cancer Cells; 3.7.3 Se-Methyl-selenocysteine (Se-MSC) Action in Cancer Cells; 3.7.4 Methylseleninic Acid (MSA) Action in Cancer Cells; 3.8 Perspectives: Future of Selenium Application in Cancer; References.
- Chapter 4: Zinc and Zinc-Dependent Proteins in Cancer and Chemotherapeutics4.1 Introduction; 4.2 Zn Homeostasis and Dysregulation; 4.2.1 Zn Transporters; 4.2.2 Metallothionein; 4.2.3 Role of Zn Homeostasis in Chemotherapeutics; 4.3 Proteins Containing Catalytic Zn; 4.3.1 Matrix Metalloproteinases; 4.3.2 Lysine Deacetylases; 4.4 Proteins Containing Structural Zn; 4.4.1 Zn Finger Proteins; Specificity Protein 1; Snail Homolog 1; Glioma-Associated Oncogene; 4.4.2 p53; 4.5 Summary; References; Chapter 5: Arsenic Carcinogenesis; 5.1 Introduction; 5.2 Cancer Epidemiology; 5.2.1 Skin Cancers.
