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|a Continuous biomanufacturing :
|b innovative technologies and methods /
|c edited by Ganapathy Subramanian.
|
| 264 |
|
1 |
|a Weinheim :
|b Wiley-VCH,
|c [2018]
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4 |
|c ©2018
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|a 1 online resource
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|a text
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|a online resource
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| 504 |
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|a Includes bibliographical references and index.
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| 505 |
0 |
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|a Continuous Biomanufacturing: Innovative Technologies and Methods; Contents; List of Contributors; Part One: Overview of State-of-the-Art Technologies and Challenges; Chapter 1: Continuous Bioprocess Development: Methods for Control and Characterization of the Biological System; 1.1 Proposed Advantages of Continuous Bioprocessing; 1.1.1 Introduction; 1.2 Special Challenges for Continuous Bioprocesses; 1.2.1 The Biological System in Continuous Biomanufacturing; 1.2.2 Inherent Changes in the Microbial System -- Problem of Evolution; 1.2.3 Lack of Process Information.
|
| 505 |
8 |
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|a 1.2.3.1 Models-Based Process Development and Control for Continuous Processes1.2.3.2 Engineering Approach to Complex Systems; 1.2.4 Limited Control Strategies; 1.2.4.1 Traditional Control Strategies for Continuous Cultures; 1.3 Changes Required to Integrate Continuous Processes in Biotech; 1.3.1 A Better Physiological Understanding of the Organisms and Their Responses on the Reactor Environment; 1.3.1.1 Model Complexity; 1.3.1.2 Models; 1.3.2 Model-Based Process Monitoring; 1.3.3 Implementation of Model Predictive Control; 1.3.3.1 Model-Based Control.
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| 505 |
8 |
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|a 1.4 Role of Iterative Process Development to Push Continuous Processes in Biotech1.4.1 Methods for Development of Continuous Processes; 1.4.1.1 Alternative: Fed-Batch as a System to Simulate Quasi Steady-State Conditions; 1.4.2 Mimicking Industrial Scale Conditions in the Lab: Continuous-Like Experiments; 1.4.2.1 A Simple Model for Continuous Processes; 1.4.2.2 Continuous-Like Fed-Batch Cultivations; 1.4.3 Fast and Parallel Experimental Approaches with High Information Content; 1.4.3.1 Computer-Aided Operation of Robotic Facilities; 1.4.3.2 Model Building and Experimental Validation.
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| 505 |
8 |
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|a 1.5 ConclusionsReferences; Chapter 2: Tools Enabling Continuous and Integrated Upstream and Downstream Processes in the Manufacturing of Biologicals; 2.1 Introduction; 2.2 Continuous Upstream Processes; 2.2.1 Continuous Bioprocesses: With or Without Cell Recycle?; 2.2.2 Early/Scale-Down Perfusion Development; 2.2.3 Feeding and Operational Strategies in Perfusion Processes; 2.2.4 Cell Retention Devices; 2.3 Continuous Downstream Processes; 2.3.1 Continuous Liquid Chromatography (CLC); 2.3.1.1 Continuous Annular Chromatography (CAC).
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| 505 |
8 |
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|a 2.3.1.2 True and Simulated Moving Bed Chromatography (TMB/SMB)2.3.1.3 Multicolumn Countercurrent Solvent Gradient Purification (MCSGP); 2.3.1.4 Periodic Countercurrent Chromatography (PCC); 2.3.1.5 Continuous Countercurrent Tangential Chromatography (CCTC); 2.3.2 Nonchromatographic Continuous Processes; 2.3.2.1 Continuous Aqueous Two-Phase Systems; 2.3.2.2 Continuous Protein Precipitation; 2.3.3 Straight-Through Processes; 2.3.4 Continuous Virus Clearance Processes; 2.4 Integrated Continuous Processes; 2.5 Concluding Remarks; References.
|
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|a Online resource; title from PDF title page (EBSCO, viewed September 29, 2017).
|
| 590 |
|
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
|
| 650 |
|
0 |
|a Pharmaceutical biotechnology.
|
| 650 |
|
0 |
|a Biopharmaceutics.
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| 650 |
|
0 |
|a Biochemical engineering.
|
| 650 |
|
0 |
|a Biologicals.
|
| 650 |
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2 |
|a Manufactured Materials
|x trends
|
| 650 |
|
2 |
|a Biological Products
|
| 650 |
|
2 |
|a Biopharmaceutics
|
| 700 |
1 |
|
|a Subramanian, G.,
|d 1935-
|e editor.
|1 https://id.oclc.org/worldcat/entity/E39PCjyHMWqm49Ypv3r89HFGDy
|
| 758 |
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|i has work:
|a Continuous biomanufacturing (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCH8ykWfkP9rMgqTRFfVcj3
|4 https://id.oclc.org/worldcat/ontology/hasWork
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