Evidence synthesis in the baseline natural history model /

This Technical Support Document reviews synthesis issues that arise on the construction of a baseline natural history model. The intention is to cover both the absolute response to treatment on the outcome measures on which comparative effectiveness is defined, and also other elements of the natural...

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Online Access: http://www.ncbi.nlm.nih.gov/books/NBK310368/
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Main Authors: Dias, Sofia, 1977- (Author), Welton, Nicky J. (Author), Sutton, A. J. (Author), Ades, A. E. (Author)
Format: Electronic eBook
Language:English
Published: London : National Institute for Health and Care Excellence (NICE), 2012
Edition:Updated.
Series:NICE DSU technical support document ; 5.
Subjects:

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520 3 |a This Technical Support Document reviews synthesis issues that arise on the construction of a baseline natural history model. The intention is to cover both the absolute response to treatment on the outcome measures on which comparative effectiveness is defined, and also other elements of the natural history model, which are usually "downstream" of the shorter-term effects reported in trials. The TSDs provide a review of the current state of the art in each topic area, and make clear recommendations on the implementation of methods and reporting standards where it is appropriate to do so. They aim to provide assistance to all those involved in submitting or critiquing evidence as part of NICE Technology Appraisals, whether manufacturers, assessment groups or any other stakeholder type. 
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