Small peptides : chemistry, biology, and clinical studies

Small peptides : chemistry, biology, and clinical studies /

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Bibliographic Details
Main Author: Dutta, A. S. (Anand S.)
Format: Book
Language:English
Published: Amsterdam ; New York : Elsevier, 1993
Series:Pharmacochemistry library ; v. 19.
Subjects:
Peptide hormones > Agonists.
Peptide hormones > Antagonists.
Neuropeptides > Agonists.
Neuropeptides > Antagonists.
Protein drugs.
Table of Contents:
  • Angiotensin II
  • Receptor subtypes of angiotensin II
  • Agonist analogues of angiotensin II
  • Peptide antagonists of angiotensin II
  • Non-peptide antagonists of angiotensin II
  • Non-peptide antagonists of angiotensin II acting at the ATâ‚‚ receptor
  • Bombesin/gastrin-releasing peptide
  • Antagonists of bombesin/GRP
  • Conformationally restricted analogues of bombesin
  • Bombesin/GRP antagonists and cancer
  • Bradykinin analogues
  • Receptor subtypes of bradykinin
  • Agonist analogues of bradykinin
  • Antagonists of bradykinin
  • Biological profile of HOE 140 and related antagonists
  • Side effects associated with bradykinin antagonists
  • Cholecystokinin analogues
  • Distribution and biological functions of cholecystokinin
  • Cholecystokinin receptor subtypes and receptor-selective ligands
  • Peptide antagonists of cholecystokinin and gastrin
  • Non-peptide antagonists of CCK and gastrin
  • Enkephalin analogues
  • Enzymic inactivation of enkephalins
  • Early structure activity relationship studies
  • Agonist analogues displaying analgesic activity.
  • (cont) Analogues with improved selectivity for the mu and delta receptors
  • Antagonists of enkephalins
  • Luteinising hormone releasing hormone
  • Enzymic degradation of LHRH
  • SAR of LHRH agonists
  • SAR of LHRH antagonists
  • LHRH antagonists and histamine release
  • Hexapeptide derivatives as LHRH antagonists
  • Ketaconazole derivatives as LHRH antagonists
  • Formulations of LHRH and the analogues
  • Pharmacological and clinical studies with LHRH agonists and antagonists
  • Somatostatin
  • Enzymatic degradation of somatostatin and analogues agonist analogues of somatostatin. SAR studies
  • Clinical applications of somatostatin analogues
  • Tachykinins
  • Substance P, neurokinin A and neurokinin B
  • Receptor subtypes of tachykinins
  • SAR of the mammalian tachykinins
  • Antagonists of substance P
  • Antagonists of neurokinin A and neurokinin B
  • Non-peptide antagonists of the tachykinins
  • Biological studies using SP analogues
  • Inhibitors of aspartyl proteases.1.renin
  • Inhibitors of renin
  • Inhibitors of aspartyl proteases.2.HIV protease.
  • (cont) Nature of the enzyme
  • Chemical approaches used in the design of inhibitors
  • Non-peptide inhibitors of HIV protease
  • Metallopeptidase (ace, enkephalinase and atriopeptidase) inhibitors
  • Inhibitors of angiotensin converting enzyme
  • Inhibitors of enkephalin degrading dipeptidyl-carboxypeptidase (enkephalinase)
  • Inhibitors of atrial natriuretic factor (ANF) degrading enzyme
  • Formulation of peptides
  • Polymeric controlled drug delivery systems (depot formulations)
  • Improvements in the oral delivery of peptides
  • Intranasal administration of peptides
  • Transdermal iontophoretic drug delivery of peptides
  • Administration of peptides by ocular, vaginal and rectal routes.

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